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KMID : 1234420110390030313
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Korean Journal of Microbiololgy and Biotechnology
2011 Volume.39 No. 3 p.313 ~ p.316
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Characteristics of immunomodulation by a Lactobacillus sakei proBio65 isolated from Kimchi
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Lim Jeong-heui
Seo Byoung-Joo
Kim Jung-Eun
Chae Chang-Suk
Im Sin-Hyeog
Hahn Youn-Soo
Park Yong-Ha
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Abstract
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We isolated and identified a novel probiotic strain, Lactobacillus sakei proBio65 from Kimchi. To determine whether L. sakei proBio65 has an immunomodulatory effect, we investigated cells via an in vitro screening system which co-cultured freshly isolated mesenteric lymphocyte with probiotics. A significant increase of Foxp3+ transcription regulatory factor expression was observed, followed by an increase in anti-inflammatory cytokines transcription regulatory factor. L. sakei proBio65 exhibited high levels of the IL-10/IL-12 production ratio and enhanced Foxp3 expression in vitro. L. sakei proBio65 may thus be therapeutically useful for the modulation of inflammatory immune disorders.
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KEYWORD
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Lactobacillus sakei proBio65, regulatory T cell, anti-inflammation, interleukin-10, interleukin-12
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